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The Ultimate Guide to Muscle Protein Synthesis

Last updated: December 11, 2025 By Jorn Trommelen 493 Comments

Ultimate guide MPS front cover

Muscle protein synthesis is the process by which muscle mass is built.

Muscle protein synthesis is essential for exercise recovery and adaptation. As such, it’s a really popular topic in the fitness community.

But the methods used to measure muscle protein synthesis in studies are very complicated. Some basic knowledge of the various techniques is essential to draw proper conclusions from the research you’ll read.

The purpose of this article is to provide a comprehensive guide on muscle protein synthesis: what is it, how is it measured, what are the strengths and limitations, how to draw proper conclusions from muscle protein synthesis research, and of course practical guidelines how to optimize it.

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How Long Should You Rest between Sets for Muscle Growth?

Last updated: May 8, 2016 By Jorn Trommelen 5 Comments

Muscle protein synthesisHow long are your rest intervals between sets?

1 min? 2 min? 5 min?

It’s not even unusual for powerlifters to take 10 minutes between sets.

Or do you go totally by feel?

Longer rest intervals means you’ll be fresher at the start of the next set and can do more weight or reps. On the other hand, with shorter rest intervals the muscle never fully recovers, which might be stressfull for the muscle, forcing it to adapt.

So what rest interval is best to build muscle? Does it even matter?

I reveal new research in this new video.

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Why Fructose and Sucrose are Beneficial for Athletes

Last updated: November 13, 2018 By Jorn Trommelen 1 Comment

White Sugar Sucrose

Sugar is bad.

We all know that, right?

Well, not so fast.

Sure, sugar is bad if you’re a couch potato with a pot belly. But for athletes, sugar may be your best friend.

Let me tell you all about the role of sugar in sports nutrition and my recent scientific publication on the topic!

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Spit or swallow? Carbohydrate mouth rinse and performance.

Last updated: November 16, 2015 By Jorn Trommelen 1 Comment

Carbohydrate mouth rinse nutrition tacticsWhy wouldn’t you actually swallow the carbs?

It was the first day of my PhD.

We’re discussing how carbohydrate mouth rinsing might increase performance. In other words, how swirling a sports drink through your mouth for a few seconds and then spitting it out, might make you faster.

It sounded like a ‘scientifically interesting, but no practical applications whatsoever’ type of research.

Why would you do all that trouble with rinsing and spitting it out?

Actually drinking your sports drink must be much more effective, right?

[Read more…]

Does Insulin Stimulate Muscle Growth?

Last updated: November 13, 2018 By Jorn Trommelen 46 Comments

Muscle.

You probably heard about insulin before.

It’s the hormone that’s released when you eat those tasty carbohydrates and that makes you fat. At least, that is what all your diet books have told you right?

But if insulin is so bad for your physique, then why do bodybuilders inject insulin?

Well I’m glad you asked.

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The Shocking Truth About Rep Ranges

Last updated: February 3, 2015 By Jorn Trommelen 40 Comments

You know how it is.

Low reps mostly build strength. High reps mostly build endurance. Six to fifteen reps, that’s where it’s at for building muscle, everyone will tell you.

But you can’t help wondering.

Why are weight lifters so big then? Why are some of the biggest guys in the gym always busting out using high reps? Why are they bigger then you?

Do you just need to be patient, or could it be, that really, you’ve been doing it wrong all along?

[Read more…]

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