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How effective is HMB for muscle growth?

Last updated: January 30, 2023 By Jorn Trommelen 3 Comments

How effective is HMB for muscle growth? Infographic

Does HMB supplementation result in incredible muscle mass gains?

Protein ingestion can help improve muscle mass gains during resistance training. Protein consists out of amino acids, of which leucine is the most potent to stimulate muscle protein synthesis (the process that drives muscle growth). Ingested leucine is partly metabolized into HMB. However, HMB can also be produced as a supplement.

Some previous research has reported that supplemental HMB resulted in ~5 times greater muscle mass gains than you typically see in similar protein/amino acid supplementation studies. However, these findings have been questioned by some of the leading muscle and protein researchers.

This study investigated the impact of HMB or leucine supplementation on muscle growth during a 12-week resistance training program. Importantly, the study design was very similar to the previous studies that claimed exceptionally large increases in muscle mass gains with HMB.

HMB did not increase muscle mass gains more than leucine. Both groups only had a 2-3 kg increase in lean mass, which is much less than the 7-9 kg that was previously reported for HMB.

Therefore, HMB does not seem to be an exceptional supplement that increases muscle mass gains to extraordinary levels. In general, be skeptical about supplement research that looks too good to be true. Wait until it is replicated by multiple researchers with good reputations.

In conclusion, HMB supplementation does not result in greater muscle mass gains as compared to leucine.

Study:
Jakubowski et al. Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- Or Leucine-supplemented Men. Med Sci Sports Exerc, 2019

Go to the next infographic in the supplement series:
Oxidative stress is good for training adaptation?

Comments

  1. Neal says

    July 26, 2024 at 1:20 pm

    I’ve just seen the propaganda and it’s always “massive gains”, and “I’m ripped!”, then you buy it and work out like a maniac for months and you just aren’t seeing those types of increases, all the while dumping hundreds of dollars. Leucine is cheap, this is not.

    Reply
  2. Homo says

    August 9, 2023 at 5:33 am

    Another false article written by a stupid person that knows nothing about HMB or bodybuilding.

    Reply
    • Jorn Trommelen says

      December 6, 2023 at 4:10 pm

      Thank you for the constructive feedback.

      Reply

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