Comments on: Casein Ingestion Does Not Increase Muscle Connective Tissue Protein Synthesis Rates

By: Stefan Kunze

Stefan Kunze — Wed, 19 Aug 2020 14:51:29 +0000

Hello Jorn, is my impression correct that connective tissue seems to be the bottleneck for most athletes? (as opposed to contractile tissue). does this effect get worse as athletes age?

By: Jorn Trommelen

Jorn Trommelen — Mon, 17 Aug 2020 18:58:34 +0000

In reply to Tamer Gezici.

Nope, I see no scenario in which BCAA supplementation is the preferred option.

To stimulate MPS, you need all the essential amino acids in sufficient quantity. If not sufficient of the other EAA are present, then you would oxidize the BCAA (regardless of exercise).

Amino acids are not the preferred substrate during exercise. So if you ingested free amino acids, you wouldn’t necessarily oxidize them during exercise. Your body would use other substrates.

By: Tamer Gezici

Tamer Gezici — Sun, 16 Aug 2020 07:12:49 +0000

Do you suggest taking a BCAA supplement before, during or after strength/resistance training? I feel like, for some reason, BCAA intake during exercise, since they would be freely available. Would lead to them getting oxidized and not actually simulating MPS. What do you think?

Thanks!

By: Jorn Trommelen

Jorn Trommelen — Sat, 15 Aug 2020 07:01:07 +0000

In reply to Sven Debruyne.

Thank you Seven,

Yeah I don’t see collagen in the mg dose range doing anything.
But at doses in the gram range, perhaps there could be something to it.

If collagen supplementation turns to be effective, I would not expect much difference between the different sources (bovine, chicken etc..). In the end, it just has to provide the right amino acid precursors and they would all be suitable for that. It has been suggested that collagen might also have unique bioactive peptides (which could differ between sources), but I’m highly sceptical there’s anything to that.

By: Jorn Trommelen

Jorn Trommelen — Sat, 15 Aug 2020 06:58:04 +0000

In reply to M.

Yep, me too.

In the perfect word, also:
– a high-dose protein matched for glycine and/or proline treatment
– vitamin C co-ingestion treatments

By: Sven Debruyne

Sven Debruyne — Fri, 14 Aug 2020 15:43:54 +0000

I have been seeing a lot of attention around collagen supplements lately. I never thought it was worth persueing as most “joint support” supplements add in 40mg of UCII collagen claiming it to be the clinical dose.
Maybe it would be worthwile to look into these “20g of collagen protein” kind of shakes to add to the pre-sleep supplementation. After all, connective tissue repair is just as important as contractile tissue growth. Maybe it could help prevent or heal tendon injuries which are the majority (in my case anyway).
There do seem to be specific types thought so not sure which might be best and why, if there is any difference at all to begin with. I’ve seen bovine based, marine based, chicken based,…
Your articles always get me rethinking what i (thought) i knew, great stuff!

regards,

Sven

By: M

Fri, 14 Aug 2020 15:37:35 +0000

I’d love to see protein vs collagen vs glycine.